dr

Doctor, a title used before a doctor's name or surname (Dr Jane Doe, Dr Doe)

The defenders, Drs Smith and Lowe, ought not to have detained the pursuer in their said asylum.

drive, used in street names

debit

debitor

Abbreviation of drums (of a rock band)

Abbreviation of debtor, debit.

Abbreviation of drive.

Abbreviation of doctor.

Probably a real change would be the cure the drs can't find.

Initialism of drug-resistant (used to refer to strains of tuberculosis).