acerbation

Bitterness of feeling.

And Dolly's acerbation was aroused by a belief on her part that the money asked for trousers took him generally to race-courses.

As a result of this midwinter acerbation, men on both sides of Philadelphia had ample a reason to feel they contended for nothing less than "the right cause" in the rescue and revival of Britain's imperial destinies.

Exacerbation, aggravation, deterioration.

There is, however, significant acerbation of the impact of further episodes of hypoglycemia on cognitive function, so that this risk should be recognized and borne in mind by those receiving or initiating protocols likely to produce such hypoglycemia.