i Register
In some senses, botheration is marked as dated, humorous. Watch for register when choosing this word.
intj
A mild expression of annoyance or exasperation: bother!
"Botheration ! Who cares ? Why don't you ask if [our ancestors] carried pocket-books ?"
Botheration! How she had crumpled her skirt, kneeling in that idiotic way.
noun
The state of being bothered; annoyance, vexation.
1803, William Blake, Letter to his brother James Blake dated 30 January, 1803, in The Poetry and Prose of William Blake, edited by David V. Erdman, New York: Doubleday Anchor, 1970, p. 696, I write in great haste & with a head full of botheration about various projected works …
[...] I am determined to be peevish after my long day's botheration.
An act of bothering or annoying.
A person or thing that causes bother, inconvenience, trouble, etc.
[...] the by-products and botherations that go with pleasures make it hardly worth it. Sex is supposedly life's greatest pleasure and look what it gives you.