devastate

To ruin many or all things over a large area, such as most or all buildings of a city, or cities of a region, or trees of a forest.

Halifax in Canada was devastated by a ship exploding in 1917. SS Mont Blanc, a French vessel loaded with 2.9 kilotons of explosives, collided with the Imo.

To destroy a whole collection of related ideas, beliefs, and strongly held opinions.

To break beyond recovery or repair so that the only options are abandonment or the clearing away of useless remains (if any) and starting over.

To greatly demoralize, to cause to suffer intense grief or dismay