distune

To put (something) out of tune.

[…] the clapper of his distuned belle May cankre soone I mene his false tonge Be doumbe for euer & neuer efte to be runge

And as the Musician neyther streyneth the string of his instrument to hye, for feare of breaking, nor lette[t]h it to low for feare of distuning. So god […] will keepe a meane neyther suffering vs to be carelesselye secure, nor driuing vs for want of comforte to despayre.

To cause (something) not to be in harmony or to be poorly adjusted.

1654, Thomas Jackson, A Treatise of the Primaeval Estate of the First Man, Section 2, Chapter 13, in An Exact Collection of the Works of Doctor Jackson, London: Timothy Garthwait, p. 3037, But by eating of the forbidden fruit, and losse of Paradise, his very substance was corrupted and deprived of Life Spiritual: and all his Powers or Faculties not only corrupted, but distuned.

1802, Charles Lamb, John Woodvil, Act IV, in The Works of Charles Lamb, London: C. and J. Ollier, 1818, Volume 1, p. 146, O most distuned, and distempered world, where sons talk their aged fathers into their graves!