irk

to irritate; annoy; bother

It irks me doing all this work and have someone wreck it.

Let no man pray to Māna-Yood-Sushāī, for who shall trouble Māna with mortal woes or irk him with the sorrows of all the houses of Earth?

An annoyance.

The trade-off between computation cost and precision results in tuning parameters […] being exposed to the user, a major irk to practitioners of data science.

A river in Greater Manchester, England, which joins the River Irwell in Manchester city centre.