i Register
In some senses, irritate is marked as obsolete. Watch for register when choosing this word.
verb
To provoke impatience, anger, or displeasure in.
If thou irritatest my lord, there will come to war against thee all the Getulians, Numidians, and Garamantes, Afric contains.
Thou scandalizest me and irritatest my nature as much as it possibly can be irritated.
To cause or induce displeasure or irritation.
To induce pain in (all or part of a body or organism).
verb
To render null and void.
c. 1634-1661 John Bramhall, Protestants' Ordination Defended Are human laws presently superfluous, so often as they do not irritate or abrogate Divine laws ?