malignancy

The state of being malignant or diseased.

A malignant cancer; specifically, any neoplasm that is invasive or otherwise not benign.

That which is malign; evil, depravity, malevolence.

[T]he malignancie of my fate, might perhaps diſtemper yours; […]

A cold wind swept down from it and set us shivering. Somewhere there, on that desolate plain, was lurking this fiendish man, hiding in a burrow like a wild beast, his heart full of malignancy against the whole race which had cast him out.