materially

In a material manner; with regard to physical things or characteristics.

Tobacco, for instance, shrinks materially by frequent reshippings, and as all goods are warehoused as a convenience to importers, duties should be paid on what the importer receives.

To a significant degree.

In cases of extreme thickening of the coats of the stomach, of a scirrhoid character, where the suffering patients are almost worn out with constant pain, such remedies, applied over the epigastrium, most materially alleviate the distress.