melancholy

Black bile, formerly thought to be one of the four "cardinal humours" of animal bodies.

Melancholy, cold and dry, thick, black, and sour, […] is a bridle to the other two hot humours, blood and choler, preserving them in the blood, and nourishing the bones.

Great sadness or depression, especially of a thoughtful or introspective nature.

My mind was troubled with deep melancholy.

I have neither the scholar’s melancholy, which is emulation; nor the musician’s, which is fantastical; nor the courtier’s, which is proud; nor the soldier’s, which is ambitious; nor the lawyer’s, which is politic; nor the lady’s, which is nice; nor the lover’s, which is all these; but it is a melancholy of mine own, compounded of many simples, extracted from many objects, and, indeed, the sundry contemplation of my travels; in which my often rumination wraps me in a most humorous sadness.

Affected with great sadness or depression.

Melancholy people don't talk much.

[…] he is melancholy without cause, and merry against the hair: […]