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In some senses, screwup is marked as colloquial. Watch for register when choosing this word.
screwup
noun 3
Definitions
noun
1
A substantial mistake, usually causing problems for more people than just the person or group who made it.
The Ford administration emerged in better shape than it deserved from the fantastic screw-up that preceded the release of the Rockefeller...
2
A person who often makes substantial mistakes; a bungler.
3
A person who is mentally or emotionally damaged.
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