thwart

Placed or situated across something else; cross, oblique, transverse.

Which elſe to ſeveral Sphears thou muſt aſcribe, / Mov'd contrarie with thwart obliquities, / Or ſave the Sun his labour, and that ſwift / Nocturnal and Diurnal rhomb ſuppos'd, / Inviſible elſe above all Starrs, the Wheele / Of Day and Night; […]

Of people: having a tendency to oppose; obstinate, perverse, stubborn.

[…] harke Nature, heare deere Goddeſſe, ſuſpend thy purpoſe, if thou did'ſt intend to make this creature fruitful into her wombe, conuey ſterility, drie vp in hir the organs of increaſe, and from her derogate body neuer ſpring a babe to honour her, if ſhee muſt teeme, create her childe of ſpleene, that it may liue and bee a thourt diſuetur'd^([sic – meaning disnatured]) torment to her, […]

[…] and it is without all controuerſie, that learning doth make the minds of men gentle, generous, maniable, and pliant to gouernment; whereas Ignorance makes them churliſh, thwart, and mutinous; […]

Of situations or things: adverse, unfavourable, unlucky.

Across the direction of travel or length of; athwart, crosswise, obliquely, transversely.

With adverſe blaſt up-turns them from the South / Notus and Afer black with thundrous Clouds / From Serraliona; thwart of theſe as fierce / Forth ruſh the Levant and the Ponent VVindes / Eurus and Zephir with their lateral noiſe, / Sirocco, and Libecchio.

Across, athwart.