frustrate

To disappoint or defeat; to vex by depriving of something expected or desired.

It frustrates me to do all this work and then lose it all.

To hinder or thwart.

My clumsy fingers frustrate my typing efforts.

Perhaps it was the too-tooing of the youth on the coach horn which frustrated the proposal, and made it appear ludicrous rather than insultive to her ears.

To cause stress or annoyance.

This test frustrates me because if I fail, it'll destroy my grade.

ineffectual; useless; fruitless.

Our frustrate search.

In all eternity I had one chance One few years' term of gracious human life […] And this sole chance was frustrate from my birth A mockery, a delusion; […]